CACYBP anticorps (Middle Region) (Fluoro550)

N° du produit ABIN7974229

L’anticorps anti-CACYBP Polyclonal Lapin est utilisé pour la détection de CACYBP dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour CACYBP anticorps (Middle Region) (Fluoro550) (ABIN7974229)

Antigène: CACYBP (Calcyclin Binding Protein (CACYBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACYBP est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-CACYBP anticorps (Fluoro550)

Épitope: Middle Region

Fonction: Anti-SIAH Interacting Protein/CACYBP Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat,mouse sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human CACYBP, identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CACYBP

Antigène: CACYBP (Calcyclin Binding Protein (CACYBP))

Autre désignation: CACYBP

Sujet:

Background: CACYBP (Calcyclin-binding protein), also called SIP, is a protein that in humans is encoded by the CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, SIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP protein function.

Gene Full Name: calcyclin binding protein

Sequence Similarities: Contains 1 CS domain.

ID gène: 27101

UniProt: Q9HB71

Pathways: Response to Growth Hormone Stimulus