Cathepsin L anticorps (Middle Region)

N° du produit ABIN7975964

Cet anticorps anti-Cathepsin L Polyclonal Lapin (ABIN7975964) détecte spécifiquement Cathepsin L dans WB, IHC et FACS. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Cathepsin L anticorps (Middle Region) (ABIN7975964)

Antigène: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin L est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Détail du produit anti-Cathepsin L anticorps

Épitope: Middle Region

Fonction: Anti-Cathepsin L/MEP/Ctsl Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Cathepsin L/MEP/Ctsl Antibody. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of mouse Cathepsin L/MEP/Ctsl, which shares 70% and 95% amino acid (aa) sequence identity with human CTSL, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Cathepsin L

Antigène: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Autre désignation: Ctsl

Sujet:

Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.

Gene Full Name: cathepsin L

Poids moléculaire: 20-42 kDa

ID gène: 13039

UniProt: P06797

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades