CTCF anticorps (AA 521-727) (APC)

N° du produit ABIN7976137

L’anticorps anti-CTCF Polyclonal Lapin est utilisé pour la détection de CTCF dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour CTCF anticorps (AA 521-727) (APC) (ABIN7976137)

Antigène: CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTCF est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-CTCF anticorps (APC)

Épitope: AA 521-727

Fonction: Anti-CTCF Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human CTCF shares 94%,93.1% amino acid (aa) sequence identity with mouse,rat CTCF,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CTCF recombinant protein (Position: K521-R727). Human CTCF shares 94% and 93.1% amino acid (aa) sequence identity with mouse and rat CTCF, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CTCF

Antigène: CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Autre désignation: CTCF

Sujet:

Background: Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. And this nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: CCCTC-binding factor

Sequence Similarities: Belongs to the CTCF zinc-finger protein family.

ID gène: 10664

UniProt: P49711