CD68 anticorps (Middle Region)

N° du produit ABIN7977284

Cet anticorps anti-CD68 Polyclonal Lapin (ABIN7977284) détecte spécifiquement CD68 dans IHC, FACS, WB et IF. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour CD68 anticorps (Middle Region) (ABIN7977284)

Antigène: CD68 (CD68 Molecule (CD68))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD68 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-CD68 anticorps

Épitope: Middle Region

Fonction: Anti-Macrosialin CD68 Antibody

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related rat sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of mouse CD68, different from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat Immunofluorescence, 5 μg/mL, Mouse Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Mouse

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CD68

Antigène: CD68 (CD68 Molecule (CD68))

Autre désignation: CD68

Sujet:

Background: CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and other mononuclear phagocytes. Macrosialin, if not glycosylated, has the main sequence that consists of 354 amino acids with an expected molecular weight of 37.4 kD. CD68, which can be located in the cytoplasmic granules of a variety of blood cells and myocytes, can be detected via immunohistochemistry. It's particularly effective as a marker for monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts, all of which belong to the macrophage lineage. CD68 is expressed in tissue macrophages and to a lesser extent in dendritic cells. CD68 is involved in tissue macrophage phagocytic activities, as well as intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It works by binding to tissue and organ-specific lectins or selectins, enabling macrophage subsets to be ed to specific locations. Macrophages may be able to crawl over selectin-bearing substrates or other cells if CD68 is rapidly recirculated from endosomes and lysosomes to the plasma membrane.

Gene Full Name: CD68 antigen

Sequence Similarities: Belongs to the LAMP family.

Poids moléculaire: 90-100 kDa

ID gène: 12514

UniProt: P31996