C4orf49 anticorps (AA 1-155) (HRP)

N° du produit ABIN7980109

L’anticorps anti-C4orf49 Polyclonal Lapin est utilisé pour la détection de C4orf49 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour C4orf49 anticorps (AA 1-155) (HRP) (ABIN7980109)

Antigène: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C4orf49 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-C4orf49 anticorps (HRP)

Épitope: AA 1-155

Fonction: Anti-MGARP Antibody HRP Conjugated

Homologie: Human C4orf49,MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49,MGARP.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur C4orf49

Antigène: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Autre désignation: MGARP

Sujet:

Background: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

Gene Full Name: mitochondria localized glutamic acid rich protein

ID gène: 84709

UniProt: Q8TDB4