Claudin 18 anticorps (AA 31-261) (Fluoro488)

N° du produit ABIN7980403

L’anticorps anti-Claudin 18 Polyclonal Lapin est utilisé pour la détection de Claudin 18 dans des échantillons de Humain et Rat. Il a été validé pour FACS.

Aperçu rapide pour Claudin 18 anticorps (AA 31-261) (Fluoro488) (ABIN7980403)

Antigène: Claudin 18 (CLDN18)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 18 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-Claudin 18 anticorps (Fluoro488)

Épitope: AA 31-261

Fonction: Anti-Claudin18/CLDN18 Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Claudin18/CLDN18 recombinant protein (Position: S31-V261).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Claudin 18

Antigène: Claudin 18 (CLDN18)

Autre désignation: CLDN18

Sujet:

Background: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Full Name: claudin 18

ID gène: 51208

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C