Claudin 3 anticorps (C-Term) (Cy3)

N° du produit ABIN7980457

L’anticorps anti-Claudin 3 Polyclonal Lapin est utilisé pour la détection de Claudin 3 dans des échantillons de Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Claudin 3 anticorps (C-Term) (Cy3) (ABIN7980457)

Antigène: Claudin 3 (CLDN3)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 3 est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-Claudin 3 anticorps (Cy3)

Épitope: C-Term

Fonction: Anti-Claudin 3/CLDN3 Antibody Cy3 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Claudin 3/CLDN3, which shares 73.3% and 94.1% amino acid (aa) sequence identity with human and rat Claudin 3/CLDN3, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Claudin 3

Antigène: Claudin 3 (CLDN3)

Autre désignation: Cldn3

Sujet:

Background: Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology.

Gene Full Name: claudin 3

ID gène: 12739

UniProt: Q9Z0G9

Pathways: Hepatitis C