PAR1 anticorps (AA 137-432) (APC)

N° du produit ABIN7980727

L’anticorps anti-PAR1 Polyclonal Lapin est utilisé pour la détection de PAR1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour PAR1 anticorps (AA 137-432) (APC) (ABIN7980727)

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAR1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-PAR1 anticorps (APC)

Épitope: AA 137-432

Fonction: Anti-PAR1/Thrombin Receptor/F2r Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived rat PAR1/Thrombin Receptor/F2r recombinant protein (Position: R137-A432).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PAR1

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Autre désignation: F2r

Sujet:

Background: Proteinase-activated receptor 1  (PAR1), also known as the coagulation factor II (thrombin) receptor, is a protein that in humans is encoded by the F2R gene. By fluorescence in situ hybridization, this gene is mapped to 5q13, confirming its presence as a single locus in the human genome. PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. The expression of PAR1 is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft mouse model. 

Gene Full Name: coagulation factor II (thrombin) receptor

ID gène: 25439

UniProt: P26824

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus