CRTC2 anticorps (C-Term) (Fluoro488)

N° du produit ABIN7981824

Cet anticorps Lapin Polyclonal détecte spécifiquement CRTC2 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CRTC2 anticorps (C-Term) (Fluoro488) (ABIN7981824)

Antigène: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRTC2 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-CRTC2 anticorps (Fluoro488)

Épitope: C-Term

Fonction: Anti-TORC2/CRTC2 Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related rat sequence by three amino acids,and from the related mouse sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human TORC2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CRTC2

Antigène: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Autre désignation: CRTC2

Sujet:

Background: CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.

Gene Full Name: CREB regulated transcription coactivator 2

Sequence Similarities: Belongs to the TORC family.

ID gène: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis