CDCP1 anticorps (AA 74-580) (Fluoro488)

N° du produit ABIN7981957

L’anticorps anti-CDCP1 Polyclonal Lapin est utilisé pour la détection de CDCP1 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour CDCP1 anticorps (AA 74-580) (Fluoro488) (ABIN7981957)

Antigène: CDCP1 (CUB Domain Containing Protein 1 (CDCP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDCP1 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-CDCP1 anticorps (Fluoro488)

Épitope: AA 74-580

Fonction: Anti-CDCP1 Antibody Fluoro488 Conjugated

Homologie: Human CDCP1 shares 85.8% amino acid (aa) sequence identity with mouse CDCP1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CDCP1 recombinant protein (Position: E74-V580). Human CDCP1 shares 85.8% amino acid (aa) sequence identity with mouse CDCP1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CDCP1

Antigène: CDCP1 (CUB Domain Containing Protein 1 (CDCP1))

Autre désignation: CDCP1

Sujet:

Background: CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

Gene Full Name: CUB domain containing protein 1

ID gène: 64866

UniProt: Q9H5V8