DOCK3 anticorps (AA 88-2006) (Fluoro594)

N° du produit ABIN7984597

L’anticorps anti-DOCK3 Polyclonal Lapin est utilisé pour la détection de DOCK3 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour DOCK3 anticorps (AA 88-2006) (Fluoro594) (ABIN7984597)

Antigène: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DOCK3 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-DOCK3 anticorps (Fluoro594)

Épitope: AA 88-2006

Fonction: Anti-MOCA/DOCK3 Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human MOCA,DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA,DOCK3.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MOCA/DOCK3 recombinant protein (Position: E88-K2006). Human MOCA/DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA/DOCK3.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur DOCK3

Antigène: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Autre désignation: DOCK3

Sujet:

Background: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.

Gene Full Name: dedicator of cytokinesis 3

ID gène: 1795

UniProt: Q8IZD9