DBH anticorps (AA 40-545) (APC)

N° du produit ABIN7986225

Cet anticorps Lapin Polyclonal détecte spécifiquement DBH dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DBH anticorps (AA 40-545) (APC) (ABIN7986225)

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DBH est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-DBH anticorps (APC)

Épitope: AA 40-545

Fonction: Anti-Dopamine beta Hydroxylase/DBH Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Dopamine beta Hydroxylase/DBH recombinant protein (Position: S40-N545).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur DBH

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Autre désignation: DBH

Sujet:

Background: Dopamine beta-hydroxylase  (DBH), also known as dopamine beta-monooxygenase, is an enzyme  (EC1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction. It is mapped to 9q34.2. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.

Gene Full Name: dopamine beta-hydroxylase

ID gène: 1621

UniProt: P09172

Pathways: Carbohydrate Homeostasis