DCLK1 anticorps (AA 1-728) (Biotin)

N° du produit ABIN7986296

Cet anticorps anti-DCLK1 Polyclonal Lapin conjugué à Biotin (ABIN7986296) détecte spécifiquement DCLK1 dans WB, IHC et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DCLK1 anticorps (AA 1-728) (Biotin) (ABIN7986296)

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLK1 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-DCLK1 anticorps (Biotin)

Épitope: AA 1-728

Fonction: Anti-DCLK1 Antibody Biotin Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human DCLK1 shares 96.4% amino acid (aa) sequence identity with mouse DCLK1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DCLK1 recombinant protein (Position: M1-S728). Human DCLK1 shares 96.4% amino acid (aa) sequence identity with mouse DCLK1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur DCLK1

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Autre désignation: DCLK1

Sujet:

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene Full Name: doublecortin like kinase 1

ID gène: 9201

UniProt: O15075