ELANE anticorps (AA 27-265) (Fluoro594)

N° du produit ABIN7987293

Cet anticorps Lapin Polyclonal détecte spécifiquement ELANE dans FACS. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour ELANE anticorps (AA 27-265) (Fluoro594) (ABIN7987293)

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELANE est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-ELANE anticorps (Fluoro594)

Épitope: AA 27-265

Fonction: Anti-Neutrophil Elastase/ELANE Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: coli-derived mouse Elastase,ELA2.,ELA2 shares 92% amino acid (aa) sequence identity with rat Elastase,ELANE,ELA2 recombinant protein (Position: S27-N265). Mouse Elastase

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived mouse Elastase/ELANE/ELA2 recombinant protein (Position: S27-N265). Mouse Elastase/ELANE/ELA2 shares 92% amino acid (aa) sequence identity with rat Elastase/ELANE/ELA2.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ELANE

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Autre désignation: Elane

Sujet:

Background: Neutrophil elastase is a serine protease of neutrophil and monocyte granules. Its key physiologic role is in innate host defense, but it can also participate in tissue remodeling and possesses secretagogue actions important to local inflammatory responses. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

Gene Full Name: elastase, neutrophil expressed

ID gène: 50701

UniProt: Q3UP87