Plexin A1 anticorps (PE)

N° du produit ABIN749223

Cet anticorps anti-Plexin A1 est un anticorps Lapin Polyclonal détectant Plexin A1 dans FACS. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Plexin A1 anticorps (PE) (ABIN749223)

Antigène: Plexin A1 (PLXNA1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin A1 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-Plexin A1 anticorps (PE)

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Plexin A1

Isotype: IgG

Information d'application

Indications d'application: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Commentaires:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4 °C

Date de péremption: 12 months

Détails sur Plexin A1

Antigène: Plexin A1 (PLXNA1)

Autre désignation: Plexin A1

Sujet:

Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury.

Subcellular location: Extracellular

Synonyms: NOV, NOV/plexin A1 protein, NOVP, Plexin1, PlexinA1, PLXN1, PLXNA1, PLXNA1, protein, Semaphorin receptor NOV, PLXA1_HUMAN.

ID gène: 5361

Pathways: Smooth Muscle Cell Migration