EIF6 anticorps (Middle Region) (Fluoro488)

N° du produit ABIN7989157

L’anticorps anti-EIF6 Polyclonal Lapin est utilisé pour la détection de EIF6 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour EIF6 anticorps (Middle Region) (Fluoro488) (ABIN7989157)

Antigène: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF6 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-EIF6 anticorps (Fluoro488)

Épitope: Middle Region

Fonction: Anti-integrin beta 4 binding protein/EIF6 Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related rat,mouse sequences by one amino acid.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human EIF6, different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur EIF6

Antigène: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Autre désignation: EIF6

Sujet:

Background: EIF6 (Eukaryotic Translation Initiation Factor 6), also called EIF3A or ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al. (1998) mapped the ITGB4BP gene to 20q11.2. Ceci et al. (2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, EIF6 is bound to free 60S but not to 80S subunits. Furthermore, EIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al. (2008) demonstrated that mammalian eIF6 is required for efficient initiation of translation in vivo. Eif6-null mouse embryos were lethal at preimplantation. Heterozygous mice had 50 % reduction of eIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression.

Gene Full Name: eukaryotic translation initiation factor 6

Sequence Similarities: Belongs to the eIF-3 subunit B family.

ID gène: 3692

UniProt: P56537

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly