DIS3 anticorps (AA 43-878) (Fluoro488)

N° du produit ABIN7989322

L’anticorps anti-DIS3 Polyclonal Lapin est utilisé pour la détection de DIS3 dans des échantillons de Humain, Rat et Souris. Il a été validé pour FACS.

Aperçu rapide pour DIS3 anticorps (AA 43-878) (Fluoro488) (ABIN7989322)

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIS3 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-DIS3 anticorps (Fluoro488)

Épitope: AA 43-878

Fonction: Anti-DIS3 Antibody Fluoro488 Conjugated

Homologie: Human DIS3 shares 92.8% amino acid (aa) sequence identity with mouse DIS3.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DIS3 recombinant protein (Position: H43-K878). Human DIS3 shares 92.8% amino acid (aa) sequence identity with mouse DIS3.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur DIS3

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Autre désignation: DIS3

Sujet:

Background: Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. The DIS3 gene encodes a catalytic subunit of the exosome complex, an essential RNA degradation machinery involved in multiple aspects of RNA metabolism, including RNA processing, quality control, and turnover. DIS3 functions as an exonuclease, playing a key role in degrading various RNA species, such as messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). Its activity is crucial for maintaining cellular RNA homeostasis and gene expression regulation. Dysregulation of DIS3 expression or activity has been linked to various human diseases, including cancer and neurodegenerative disorders. Understanding the molecular mechanisms underlying DIS3 function is essential for elucidating its role in RNA metabolism and its potential implications for disease pathology and therapeutic targeting.

Gene Full Name: DIS3 exosome endoribonuclease and 3'-5' exoribonuclease

ID gène: 22894

UniProt: Q9Y2L1