FHIT anticorps (AA 1-147) (Cy3)

N° du produit ABIN7991734

L’anticorps anti-FHIT Monoclonal Souris est utilisé pour la détection de FHIT dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour FHIT anticorps (AA 1-147) (Cy3) (ABIN7991734)

Antigène: FHIT (Fragile Histidine Triad (FHIT))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FHIT est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Clone: 26H7

Détail du produit anti-FHIT anticorps (Cy3)

Épitope: AA 1-147

Fonction: Anti-FHIT Antibody (monoclonal, 26H7) Cy3 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human FHIT shares 90%,87% amino acid (aa) sequence identity with mouse,rat FHIT,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human FHIT recombinant protein (Position: M1-Q147). Human FHIT shares 90% and 87% amino acid (aa) sequence identity with mouse and rat FHIT, respectively.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur FHIT

Antigène: FHIT (Fragile Histidine Triad (FHIT))

Autre désignation: FHIT

Sujet:

Background: Bis (5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis (5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

Gene Full Name: fragile histidine triad diadenosine triphosphatase

ID gène: 2272

UniProt: P49789