GNE anticorps (AA 49-695) (HRP)

N° du produit ABIN7993439

Cet anticorps anti-GNE Polyclonal Lapin conjugué à HRP (ABIN7993439) détecte spécifiquement GNE dans WB, IHC et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GNE anticorps (AA 49-695) (HRP) (ABIN7993439)

Antigène: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNE est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-GNE anticorps (HRP)

Épitope: AA 49-695

Fonction: Anti-GNE Antibody HRP Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human GNEshares 98.9%,98.8% amino acid (aa) sequence identity with mouse,rat GNE,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GNE recombinant protein (Position: H49-D695). Human GNEshares 98.9% and 98.8% amino acid (aa) sequence identity with mouse and rat GNE, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur GNE

Antigène: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Autre désignation: GNE

Sujet:

Background: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Gene Full Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

ID gène: 10020

UniProt: Q9Y223