ULBP1 anticorps

N° du produit ABIN749753

L’anticorps anti-ULBP1 Polyclonal Lapin est utilisé pour la détection de ULBP1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour ULBP1 anticorps (ABIN749753)

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULBP1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ULBP1 anticorps

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ULBP1

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ULBP1

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Autre désignation: ULBP1

Sujet:

Synonyms: ALCAN-beta, N2DL-1, N2DL1, NKG2D ligand 1 precursor, NKG2DL1, RAET1I, Retinoic acid early transcript 1I, UL16, UL16 binding protein 1, UL16-binding protein 1, N2DL1_HUMAN.

Background: N2DL1 is a human rat mouse ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The interaction with UL16 blocks the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. ULBP1 is expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues.

ID gène: 80329

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process