GRB7 anticorps (AA 29-256) (PE)

N° du produit ABIN7995413

Cet anticorps anti-GRB7 Polyclonal Lapin conjugué à PE (ABIN7995413) détecte spécifiquement GRB7 dans FACS. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour GRB7 anticorps (AA 29-256) (PE) (ABIN7995413)

Antigène: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB7 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-GRB7 anticorps (PE)

Épitope: AA 29-256

Fonction: Anti-GRB7 Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GRB7 recombinant protein (Position: R29-S256).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur GRB7

Antigène: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Autre désignation: GRB7

Sujet:

Background: GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 though to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.

Gene Full Name: growth factor receptor bound protein 7

ID gène: 2886

UniProt: Q14451

Pathways: EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization