HPSE anticorps (Middle Region) (HRP)

N° du produit ABIN7997018

Cet anticorps anti-HPSE Polyclonal Lapin conjugué à HRP (ABIN7997018) détecte spécifiquement HPSE dans WB, IHC et ELISA. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour HPSE anticorps (Middle Region) (HRP) (ABIN7997018)

Antigène: HPSE (Heparanase (HPSE))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HPSE est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-HPSE anticorps (HRP)

Épitope: Middle Region

Fonction: Anti-Heparanase 1/HPSE Antibody HRP Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse,rat sequences by eight amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Heparanase 1, different from the related mouse and rat sequences by eight amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur HPSE

Antigène: HPSE (Heparanase (HPSE))

Autre désignation: HPSE

Sujet:

Background: Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis. The successful penetration of the endothelial cell layer that lines the interior surface of blood vessels is an important process in the formation of blood borne tumour metastases. Heparan sulfate proteoglycans are major constituents of this layer and it has been shown that increased metastatic potential corresponds with increased heparanase activity for a number of cell lines.

Gene Full Name: heparanase

Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.

ID gène: 10855

UniProt: Q9Y251

Pathways: Glycosaminoglycan Metabolic Process