Huntingtin anticorps (AA 3079-3142) (PE)

N° du produit ABIN7998430

L’anticorps anti-Huntingtin Polyclonal Lapin est utilisé pour la détection de Huntingtin dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour Huntingtin anticorps (AA 3079-3142) (PE) (ABIN7998430)

Antigène: Huntingtin (HTT)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Huntingtin est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-Huntingtin anticorps (PE)

Épitope: AA 3079-3142

Fonction: Anti-Huntingtin/HTT Antibody PE Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human HTT shares 93.8%,92.2% amino acid (aa) sequence identity with mouse,rat HTT,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Huntingtin/HTT recombinant protein (Position: R3079-C3142). Human HTT shares 93.8% and 92.2% amino acid (aa) sequence identity with mouse and rat HTT, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Huntingtin

Antigène: Huntingtin (HTT)

Autre désignation: HTT

Sujet:

Background: The huntingtin gene, also called HTT or HD(Huntington disease) gene, is the IT15(interesting transcript 15) gene which codes for a protein called the huntingtin protein. It is mapped to 4p16.3. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor(BDNF) at the transcription level, and this gene is required for normal development. The HTT protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. What's more, wildtype HTT may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.

Gene Full Name: huntingtin

ID gène: 3064

UniProt: P42858

Pathways: Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport