HIP1R anticorps (AA 316-734) (PE)

N° du produit ABIN7998463

L’anticorps anti-HIP1R Polyclonal Lapin est utilisé pour la détection de HIP1R dans des échantillons de Humain, Rat, Souris et Singe. Il a été validé pour FACS.

Aperçu rapide pour HIP1R anticorps (AA 316-734) (PE) (ABIN7998463)

Antigène: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIP1R est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-HIP1R anticorps (PE)

Épitope: AA 316-734

Fonction: Anti-HIP1R Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human HIP1R recombinant protein (Position: E316-E734).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur HIP1R

Antigène: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Autre désignation: HIP1R

Sujet:

Background: Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene. Huntingtin-interacting protein 1-related protein, or HIP1R, was identified on the basis of its structural homology with Huntingtin-interacting protein 1, or HIP1. Based on its domain structure, HIP1R is a putative endocytosis-related protein. Knockdown of HIP1R impairs the endocytosis of activated epidermal growth factor receptor (EGFR) and the consequent activation of the downstream ERK and Akt proteins. Additionally, HIP1R is a component of the clathrin-coated pits and vesicles, which in part links the endocytic machinery to the actin cytoskeleton. It binds to 3-phosphoinositides via ENTH domains to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1R deficiency significantly reduces the expression of the ionotropic glutamate receptor GluA1, GluN2A, and GluN2B subunits, but not the GABAA receptor α1 subunit. Knockdown of HIP1R reduces the amplitude and frequency of the miniature excitatory postsynaptic current, but not of the miniature inhibitory postsynaptic curren. HIP1R has been identified as a protein that can target histone deacetylase-3-mediated neurodegeneration, along with other proteins like NPTX1, NFL, TEX10, and TGFFG.

Gene Full Name: huntingtin interacting protein 1 related

ID gène: 9026

UniProt: O75146