HMMR anticorps (C-Term) (Fluoro647)

N° du produit ABIN7998508

L’anticorps anti-HMMR Polyclonal Lapin est utilisé pour la détection de HMMR dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour HMMR anticorps (C-Term) (Fluoro647) (ABIN7998508)

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMMR est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-HMMR anticorps (Fluoro647)

Épitope: C-Term

Fonction: Anti-CD168/HMMR Antibody Fluoro647 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human CD168.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur HMMR

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Autre désignation: HMMR

Sujet:

Background: HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.

Gene Full Name: hyaluronan mediated motility receptor

ID gène: 3161

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process