HSD17B2 anticorps (AA 75-365) (FITC)

N° du produit ABIN7998801

Cet anticorps Lapin Polyclonal détecte spécifiquement HSD17B2 dans FACS. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour HSD17B2 anticorps (AA 75-365) (FITC) (ABIN7998801)

Antigène: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B2 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-HSD17B2 anticorps (FITC)

Épitope: AA 75-365

Fonction: Anti-HSD17B2 Antibody FITC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human HSD17B2 shares 63.6%,65.2% amino acid (aa) sequence identity with mouse,rat HSD17B2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human HSD17B2 recombinant protein (Position: Q75-R365). Human HSD17B2 shares 63.6% and 65.2% amino acid (aa) sequence identity with mouse and rat HSD17B2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur HSD17B2

Antigène: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Autre désignation: HSD17B2

Sujet:

Background: HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42(43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

Gene Full Name: hydroxysteroid 17-beta dehydrogenase 2

ID gène: 3294

UniProt: P37059

Pathways: Steroid Hormone Biosynthesis