IMPA1 anticorps (AA 1-277) (Fluoro594)

N° du produit ABIN7999805

Cet anticorps Lapin Polyclonal détecte spécifiquement IMPA1 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour IMPA1 anticorps (AA 1-277) (Fluoro594) (ABIN7999805)

Antigène: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IMPA1 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-IMPA1 anticorps (Fluoro594)

Épitope: AA 1-277

Fonction: Anti-IMPA1 Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human IMPA1 shares 86.6%,85.1% amino acid (aa) sequence identity with mouse,rat IMPA1,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human IMPA1 recombinant protein (Position: M1-D277). Human IMPA1 shares 86.6% and 85.1% amino acid (aa) sequence identity with mouse and rat IMPA1, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur IMPA1

Antigène: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Autre désignation: IMPA1

Sujet:

Background: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Gene Full Name: inositol monophosphatase 1

ID gène: 3612

UniProt: P29218