IRF4 anticorps (AA 272-451) (HRP)

N° du produit ABIN8001249

L’anticorps anti-IRF4 Polyclonal Lapin est utilisé pour la détection de IRF4 dans des échantillons de Humain. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour IRF4 anticorps (AA 272-451) (HRP) (ABIN8001249)

Antigène: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF4 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-IRF4 anticorps (HRP)

Épitope: AA 272-451

Fonction: Anti-MUM1/IRF4 Antibody HRP Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human MUM1 shares 92% amino acid (aa) sequence identity with mouse MUM1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MUM1 recombinant protein (Position: E272-E451). Human MUM1 shares 92% amino acid (aa) sequence identity with mouse MUM1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur IRF4

Antigène: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Autre désignation: IRF4

Sujet:

Background: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

Gene Full Name: interferon regulatory factor 4

Sequence Similarities: Belongs to the IRF family.

ID gène: 3662

UniProt: Q15306

Pathways: Chromatin Binding