IRF4 anticorps (AA 163-419) (FITC)

N° du produit ABIN8001259

Cet anticorps anti-IRF4 Polyclonal Lapin conjugué à FITC (ABIN8001259) détecte spécifiquement IRF4 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IRF4 anticorps (AA 163-419) (FITC) (ABIN8001259)

Antigène: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF4 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-IRF4 anticorps (FITC)

Épitope: AA 163-419

Fonction: Anti-MUM1/IRF4 Antibody FITC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MUM1/IRF4 recombinant protein (Position: A163-Q419). Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur IRF4

Antigène: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Autre désignation: IRF4

Sujet:

Background: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

Gene Full Name: interferon regulatory factor 4

ID gène: 3662

UniProt: Q15306

Pathways: Chromatin Binding