Interleukin 17a anticorps (Middle Region)

N° du produit ABIN8001990

L’anticorps anti-Interleukin 17a Polyclonal Lapin est utilisé pour la détection de Interleukin 17a dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Interleukin 17a anticorps (Middle Region) (ABIN8001990)

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Interleukin 17a est non-conjugé

Application: Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-Interleukin 17a anticorps

Épitope: Middle Region

Fonction: Anti-IL17A Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-IL17A Antibody. Tested in IHC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human IL17A, which shares 88.2% amino acid (aa) sequence identity with mouse and rat IL17A.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL/mL, Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Interleukin 17a

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Autre désignation: IL17A

Sujet:

Background: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A

Gene Full Name: interleukin 17A

Poids moléculaire: 27 kDa

ID gène: 3605

UniProt: Q16552