ISOC2 anticorps (AA 1-205) (Biotin)

N° du produit ABIN8003366

Cet anticorps Lapin Polyclonal détecte spécifiquement ISOC2 dans WB, ELISA et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ISOC2 anticorps (AA 1-205) (Biotin) (ABIN8003366)

Antigène: ISOC2 (Isochorismatase Domain Containing 2 (ISOC2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ISOC2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ISOC2 anticorps (Biotin)

Épitope: AA 1-205

Fonction: Anti-ISOC2 Antibody Biotin Conjugated

Homologie: Human ISOC2 shares 84.2%,75% amino acid (aa) sequence identity with mouse,rat ISOC2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ISOC2 recombinant protein (Position: M1-H205). Human ISOC2 shares 84.2% and 75% amino acid (aa) sequence identity with mouse and rat ISOC2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur ISOC2

Antigène: ISOC2 (Isochorismatase Domain Containing 2 (ISOC2))

Autre désignation: ISOC2

Sujet:

Background: ISOC2 (isochorismatase domain-containing protein 2) is a 205 amino acid protein belonging to the isochorismatase family. Isochorismatase is an enzyme that catalyzes the chemical reaction of isochorismate and water to 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate. Localized to mitochondrion and cytoplasm, ISOC2 interacts with CDKN2A and localizes to the nucleus in the presence of it. ISOC2 is ubiquitously expressed, with highest levels found in uterus, stomach and urinary tract system. Over-expressed ISOC2 inhibits the expression of CDKN2A, suggesting that this novel gene may play a role during tumor development by interacting with CDKN2A. Three isoforms are produced by alternative splicing events.

Gene Full Name: isochorismatase domain containing 2

ID gène: 79763

UniProt: Q96AB3