Leucine Rich Transmembrane and 0-Methyltransferase Domain Containing (LRTOMT) (Middle Region) anticorps (Cy3)

N° du produit ABIN8005602

L’anticorps anti-Leucine Rich Transmembrane and 0-Methyltransferase Domain Containing Polyclonal Lapin est utilisé pour la détection de Leucine Rich Transmembrane and 0-Methyltransferase Domain Containing dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Leucine Rich Transmembrane and 0-Methyltransferase Domain Containing (LRTOMT) (Middle Region) anticorps (Cy3) (ABIN8005602)

Antigène: Leucine Rich Transmembrane and 0-Methyltransferase Domain Containing (LRTOMT)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cy3

Application: Flow Cytometry (FACS)

Détail du produit

Épitope: Middle Region

Fonction: Anti-LRTOMT Antibody Cy3 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human LRTOMT.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détail du antigène

Antigène: Leucine Rich Transmembrane and 0-Methyltransferase Domain Containing (LRTOMT)

Autre désignation: LRTOMT

Sujet:

Background: Leucine rich transmembrane and O-methyltransferase domain containing is a protein that in humans is encoded by the LRTOMT gene. It is mapped to 11q13.4. This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness.

Gene Full Name: leucine rich transmembrane and O-methyltransferase domain containing

ID gène: 220074

UniProt: Q8WZ04

Pathways: Sensory Perception of Sound