MED12 anticorps (AA 752-1974) (PE)

N° du produit ABIN8008536

L’anticorps anti-MED12 Polyclonal Lapin est utilisé pour la détection de MED12 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour MED12 anticorps (AA 752-1974) (PE) (ABIN8008536)

Antigène: MED12 (Mediator Complex Subunit 12 (MED12))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED12 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-MED12 anticorps (PE)

Épitope: AA 752-1974

Fonction: Anti-MED12 Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MED12 recombinant protein (Position: Q752-Q1974).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MED12

Antigène: MED12 (Mediator Complex Subunit 12 (MED12))

Autre désignation: MED12

Sujet:

Background: Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome. The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Gene Full Name: mediator complex subunit 12

ID gène: 9968

UniProt: Q93074

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Tube Formation