MECP2 anticorps (AA 36-437) (FITC)

N° du produit ABIN8009556

L’anticorps anti-MECP2 Polyclonal Lapin est utilisé pour la détection de MECP2 dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour FACS.

Aperçu rapide pour MECP2 anticorps (AA 36-437) (FITC) (ABIN8009556)

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MECP2 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-MECP2 anticorps (FITC)

Épitope: AA 36-437

Fonction: Anti-MECP2 Antibody FITC Conjugated

Homologie: Human MECP2 shares 95.8%,96% amino acid (aa) sequence identity with mouse,rat MECP2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MECP2 recombinant protein (Position: K36-Q437). Human MECP2 shares 95.8% and 96% amino acid (aa) sequence identity with mouse and rat MECP2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MECP2

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Autre désignation: MECP2

Sujet:

Background: MECP2?(methyl CpG binding protein 2) is a?gene?that encodes the?protein?MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: methyl-CpG binding protein 2

ID gène: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane