MGA (C-Term) anticorps (Fluoro550)

N° du produit ABIN8009884

Cet anticorps anti-MGA Polyclonal Lapin conjugué à Fluoro550 (ABIN8009884) détecte spécifiquement MGA dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MGA (C-Term) anticorps (Fluoro550) (ABIN8009884)

Antigène: MGA

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit

Épitope: C-Term

Fonction: Anti-MGA Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human MGA, different from the related mouse sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détail du antigène

Antigène: MGA

Sujet:

Background: Mga is a DNA-binding protein that activates the expression of several important virulence genes in Streptococcus pyogenes  (group A Streptococcus, GAS) in response to changing environmental conditions. It had been found that the mouse transcription factor Max interacted with Mga. Coimmunoprecipitation analysis confirmed that Max and Mga interacted in transfected HEK293 cells. EMSA revealed that Mga required Max for binding to the E-box sequence CACGTG. The isolated T-box of Mga bound the brachyury T-box-binding site in the absence of Max. Mga repressed transcription of a reporter driven from a T-box-binding site, but coexpression of Mga with Max caused transcriptional activation from the T-box-binding site. Expression of Mga with Max, but not Mga alone, activated transcription from a reporter containing the E-box site.

Gene Full Name: MAX dimerization protein MGA

ID gène: 23269

UniProt: Q8IWI9