MFAP3L anticorps (AA 29-409) (APC)

N° du produit ABIN8009976

L’anticorps anti-MFAP3L Polyclonal Lapin est utilisé pour la détection de MFAP3L dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour MFAP3L anticorps (AA 29-409) (APC) (ABIN8009976)

Antigène: MFAP3L (Microfibrillar-Associated Protein 3-Like (MFAP3L))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFAP3L est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-MFAP3L anticorps (APC)

Épitope: AA 29-409

Fonction: Anti-MFAP3L Antibody APC Conjugated

Homologie: Human MFAP3L shares 90.6% amino acid (aa) sequence identity with both mouse,rat MFAP3L.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MFAP3L recombinant protein (Position: K29-V409). Human MFAP3L shares 90.6% amino acid (aa) sequence identity with both mouse and rat MFAP3L.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MFAP3L

Antigène: MFAP3L (Microfibrillar-Associated Protein 3-Like (MFAP3L))

Autre désignation: MFAP3L

Sujet:

Background: Microbibrillar-Associated Protein 3-Like (MFAP3L), also known as NYD-sp9, is part of the microfibrillar-associated protein family (MFAPs). MFAPs are non-fibrillin, extracellular matrix glycoproteins that interact with fibrillin and were originally characterized in microfibrillar assembly. In humans, there several subfamily members with varying amino acid (aa) sequence homology and functions . Among the family, MFAP2 and MFAP5 are more closely related and while MFAP1, 3 and 4 share no structural or sequence homology with MFAP2, MFAP5 or with each other. Human MFAP3L shows 71 % amino acid (aa) sequence homology to MFAP3, but not other MFAPs. Mature, human MFAP3L consists of an extracellular domain (ECD) containing N-linked glycosylation sites, a transmembrane domain, and a cytoplasmic domain with a conserved SH2 motif. The ECD of human MFAP3L shares 89 % and 90 % aa sequence identity with mouse and rat MFAP3L, respectively. MFAPs have the unique ability to interact with TGF-beta family growth factors, Notch and Notch ligands and multiple elastic fiber proteins, in addition to interacting with fibrillin. MFAPs are expressed in a wide variety of tissues and, along with microfibril assembly, they play roles in the regulation of tissue homeostasis, cell survival, and tumor progression. MFAP3L is often located within colorectal cancer (CRC) cells, which metastasize by activation of the nuclear ERK pathway via MFAP3L phosphorylation. Regulation of this MFAP3L activity could have pharmaceutical effects on CRC tumor progression.

Gene Full Name: microfibril associated protein 3 like

ID gène: 9848

UniProt: O75121