MFN2 anticorps (AA 601-757) (Fluoro550)

N° du produit ABIN8010864

L’anticorps anti-MFN2 Polyclonal Lapin est utilisé pour la détection de MFN2 dans des échantillons de Humain, Rat et Souris. Il a été validé pour FACS.

Aperçu rapide pour MFN2 anticorps (AA 601-757) (Fluoro550) (ABIN8010864)

Antigène: MFN2 (Mitofusin 2 (MFN2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFN2 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-MFN2 anticorps (Fluoro550)

Épitope: AA 601-757

Fonction: Anti-Mitofusin 2/MFN2 Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human Mitofusin 2 shares 96%,95% amino acid (aa) sequence identity with mouse,rat Mitofusin 2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Mitofusin 2 recombinant protein (Position: V601-R757). Human Mitofusin 2 shares 96% and 95% amino acid (aa) sequence identity with mouse and rat Mitofusin 2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MFN2

Antigène: MFN2 (Mitofusin 2 (MFN2))

Autre désignation: MFN2

Sujet:

Background: Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. This gene is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. It has been found that MFN2 triggers mitochondrial energization, at least in part, by regulating OXPHOS expression through signals that are independent of its role as a mitochondrial fusion protein. And it contributes to the maintenance and operation of the mitochondrial network. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations in MFN2, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.

Gene Full Name: mitofusin 2

Sequence Similarities: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.

ID gène: 9927

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development