MBNL1 anticorps (AA 89-388) (HRP)

N° du produit ABIN8012154

L’anticorps anti-MBNL1 Polyclonal Lapin est utilisé pour la détection de MBNL1 dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour MBNL1 anticorps (AA 89-388) (HRP) (ABIN8012154)

Antigène: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MBNL1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MBNL1 anticorps (HRP)

Épitope: AA 89-388

Fonction: Anti-MBNL1 Antibody HRP Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MBNL1 recombinant protein (Position: Q89-M388).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MBNL1

Antigène: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Autre désignation: MBNL1

Sujet:

Background: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

Gene Full Name: muscleblind like splicing regulator 1

ID gène: 4154

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization