MPZ anticorps (AA 30-153) (Cy3)

N° du produit ABIN8012391

L’anticorps anti-MPZ Polyclonal Lapin est utilisé pour la détection de MPZ dans des échantillons de Humain, Rat et Souris. Il a été validé pour FACS.

Aperçu rapide pour MPZ anticorps (AA 30-153) (Cy3) (ABIN8012391)

Antigène: MPZ (Myelin Protein Zero (MPZ))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPZ est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-MPZ anticorps (Cy3)

Épitope: AA 30-153

Fonction: Anti-Myelin Protein Zero/MPZ Antibody Cy3 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Myelin Protein Zero recombinant protein (Position: I30-R153).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MPZ

Antigène: MPZ (Myelin Protein Zero (MPZ))

Autre désignation: MPZ

Sujet:

Background: Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

Gene Full Name: myelin protein zero

ID gène: 4359

UniProt: P25189