NOXA1 anticorps (Middle Region) (Fluoro550)

N° du produit ABIN8013814

Cet anticorps anti-NOXA1 Polyclonal Lapin conjugué à Fluoro550 (ABIN8013814) détecte spécifiquement NOXA1 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NOXA1 anticorps (Middle Region) (Fluoro550) (ABIN8013814)

Antigène: NOXA1 (NADPH Oxidase Activator 1 (NOXA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOXA1 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-NOXA1 anticorps (Fluoro550)

Épitope: Middle Region

Fonction: Anti-NOXA1 Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human NOXA1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur NOXA1

Antigène: NOXA1 (NADPH Oxidase Activator 1 (NOXA1))

Autre désignation: NOXA1

Sujet:

Background: NOXA1 (NADPH oxidase activator 1), also called NOX ACTIVATOR 1 or p51-NOX, is an enzyme that in humans is encoded by the NOXA1 gene. Hartz (2007) mapped the NOXA1 gene to chromosome 9q34.3 based on an alignment of the NOXA1 sequence with the genomic sequence (build 36.1). Banfi et al. (2003) mapped the mouse Noxa1 gene to chromosome 2. Using yeast 2-hybrid assays, Takeya et al. (2003) showed that human p51-NOX interacted with constitutively active forms of RAC1 and RAC2. In vitro binding assays revealed that p51-NOX bound GTP-bound RAC1, but not GDP-bound RAC1. p51-NOX also bound p47-PHOX (NCF1) and p41-NOX (NOXO1), and trp436 within the SH3 domain of p51-NOX was required for these interactions. Human cell lines or COS-7 cells cotransfected with p51-NOX and p41-NOX and either gp91-PHOX (CYBB) or NOX1 produced superoxide. Cells individually transfected with NOX1, p41-NOX, or p51-NOX and cells transfected with only p41-NOX and p51-NOX showed no superoxide production.

Gene Full Name: NADPH oxidase activator 1

Sequence Similarities: Belongs to the NCF2/NOXA1 family.

ID gène: 10811

UniProt: Q86UR1