NUB1 anticorps (AA 190-543) (APC)

N° du produit ABIN8014181

Cet anticorps Lapin Polyclonal détecte spécifiquement NUB1 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris, Singe et Rat.

Aperçu rapide pour NUB1 anticorps (AA 190-543) (APC) (ABIN8014181)

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Reactivité: Humain, Souris, Singe, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUB1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-NUB1 anticorps (APC)

Épitope: AA 190-543

Fonction: Anti-NUB1 Antibody APC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NUB1 recombinant protein (Position: K190-D543).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur NUB1

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Autre désignation: NUB1

Sujet:

Background: NEDD8 µLtimate buster 1 is a protein that in humans is encoded by the NUB1 gene. This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: negative regulator of ubiquitin like proteins 1

ID gène: 51667

UniProt: Q9Y5A7