Netrin 1 anticorps (N-Term) (Fluoro550)

N° du produit ABIN8014375

Cet anticorps anti-Netrin 1 Polyclonal Lapin conjugué à Fluoro550 (ABIN8014375) détecte spécifiquement Netrin 1 dans FACS. L’anticorps est réactif avec des échantillons de Souris, Humain et Rat.

Aperçu rapide pour Netrin 1 anticorps (N-Term) (Fluoro550) (ABIN8014375)

Antigène: Netrin 1 (NTN1)

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Netrin 1 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-Netrin 1 anticorps (Fluoro550)

Épitope: N-Term

Fonction: Anti-Netrin 1/NTN1 Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat,mouse sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Netrin 1, identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Netrin 1

Antigène: Netrin 1 (NTN1)

Autre désignation: NTN1

Sujet:

Background: Netrin-1 (NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And netrin-1 expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1, and that netrin-1-dependent outgrowth of dorsal spinal cord axons ly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumor suppressors. Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro, whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion.

Gene Full Name: netrin 1

Sequence Similarities: Contains 3 laminin EGF-like domains.

ID gène: 9423

UniProt: O95631

Pathways: Regulation of Cell Size