NSMCE4A anticorps (AA 69-380) (Fluoro647)

N° du produit ABIN8016075

L’anticorps anti-NSMCE4A Polyclonal Lapin est utilisé pour la détection de NSMCE4A dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour NSMCE4A anticorps (AA 69-380) (Fluoro647) (ABIN8016075)

Antigène: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSMCE4A est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-NSMCE4A anticorps (Fluoro647)

Épitope: AA 69-380

Fonction: Anti-NSMCE4A Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NSMCE4A recombinant protein (Position: D69-Q380).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur NSMCE4A

Antigène: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Autre désignation: NSMCE4A

Sujet:

Background: Non-SMC element 4 homolog A is a protein that in humans is encoded by the NSMCE4A gene. NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.

Gene Full Name: NSE4A component of SMC5/6 complex

ID gène: 54780

UniProt: Q9NXX6

Pathways: Positive Regulation of Response to DNA Damage Stimulus