NCOA1 anticorps (AA 614-826) (Fluoro594)

N° du produit ABIN8016786

L’anticorps anti-NCOA1 Polyclonal Lapin est utilisé pour la détection de NCOA1 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour NCOA1 anticorps (AA 614-826) (Fluoro594) (ABIN8016786)

Antigène: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA1 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-NCOA1 anticorps (Fluoro594)

Épitope: AA 614-826

Fonction: Anti-KAT13A/SRC1/NCOA1 Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human KAT13A shares 92% amino acid (aa) sequence identity with mouse KAT13A.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human KAT13A recombinant protein (Position: H614-Q826). Human KAT13A shares 92% amino acid (aa) sequence identity with mouse KAT13A.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur NCOA1

Antigène: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Autre désignation: NCOA1

Sujet:

Background: The nuclear receptor coactivator 1 (NCOA1), also known as SRC1, is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. It has been found that NCOA1 can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter. It also enhances estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone. What's more, SRC1 may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors.

Gene Full Name: nuclear receptor coactivator 1

Sequence Similarities: Belongs to the SRC/p160 nuclear receptor coactivator family.

ID gène: 8648

UniProt: Q15788

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha