NUMB anticorps (AA 59-567)

N° du produit ABIN8017794

L’anticorps anti-NUMB Polyclonal Lapin est utilisé pour la détection de NUMB dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour NUMB anticorps (AA 59-567) (ABIN8017794)

Antigène: NUMB (Numb Homolog (NUMB))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMB est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Détail du produit anti-NUMB anticorps

Épitope: AA 59-567

Fonction: Anti-NUMB Antibody

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human NUMB shares 93.7% amino acid (aa) sequence identity with both mouse,rat NUMB.

Attributs du produit: Anti-NUMB Antibody. Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NUMB recombinant protein (Position: E59-A567). Human NUMB shares 93.7% amino acid (aa) sequence identity with both mouse and rat NUMB.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Monkey, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NUMB

Antigène: NUMB (Numb Homolog (NUMB))

Autre désignation: NUMB

Sujet:

Background: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. What's more, the numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

Gene Full Name: NUMB endocytic adaptor protein

Poids moléculaire: 72-75 kDa

ID gène: 8650

UniProt: P49757

Pathways: Cell-Cell Junction Organization