Occludin anticorps (AA 358-520) (Fluoro488)

N° du produit ABIN8017896

L’anticorps anti-Occludin Polyclonal Lapin est utilisé pour la détection de Occludin dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Occludin anticorps (AA 358-520) (Fluoro488) (ABIN8017896)

Antigène: Occludin (OCLN)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Occludin est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-Occludin anticorps (Fluoro488)

Épitope: AA 358-520

Fonction: Anti-Occludin/OCLN Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human Occludin,OCLN shares 88.8%,88.2% amino acid (aa) sequence identity with mouse,rat Occludin,OCLN,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Occludin/OCLN recombinant protein (Position: S358-Q520). Human Occludin/OCLN shares 88.8% and 88.2% amino acid (aa) sequence identity with mouse and rat Occludin/OCLN, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Occludin

Antigène: Occludin (OCLN)

Autre désignation: OCLN

Sujet:

Background: Occludin is an integral membrane protein that is located at tight junctions. It is a member of a family of proteins containing the highly conserved Marvel domain, which contains 4 transmembrane-helix regions. This gene is mapped to 5q13.2. Occludin regulates TGF-beta receptor type I localization for efficient TGF-beta-dependent dissolution of tight junctions during epithelial-mesenchymal transitions. Human Occludin is an essential hepatitis C virus (HCV) cell entry factor that is able to render murine cells infectable with HCV glycoproteins. It has been found that occludin is involved in cell migration and functions to recruit active PI3 kinase to the leading edge, resulting in RAC1 activation and formation of lamellipodia.

Gene Full Name: occludin

ID gène: 100506658

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C