OPTN anticorps (AA 241-577) (APC)

N° du produit ABIN8018264

Cet anticorps Lapin Polyclonal détecte spécifiquement OPTN dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour OPTN anticorps (AA 241-577) (APC) (ABIN8018264)

Antigène: OPTN (Optineurin (OPTN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPTN est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-OPTN anticorps (APC)

Épitope: AA 241-577

Fonction: Anti-Optineurin/OPTN Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse,rat Optineurin.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur OPTN

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: OPTN

Sujet:

Background: OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene Full Name: optineurin

Sequence Similarities: Belongs to the nuclear hormone receptor family. NR3 subfamily.

ID gène: 10133

UniProt: Q96CV9

Pathways: M Phase