PDX1 anticorps (AA 1-145) (Fluoro550)

N° du produit ABIN8019342

L’anticorps anti-PDX1 Polyclonal Lapin est utilisé pour la détection de PDX1 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour PDX1 anticorps (AA 1-145) (Fluoro550) (ABIN8019342)

Antigène: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDX1 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-PDX1 anticorps (Fluoro550)

Épitope: AA 1-145

Fonction: Anti-PDX1 Antibody Fluoro550 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PDX1 shares 87.7%,86.9% amino acid (aa) sequence identity with mouse,rat PDX1,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PDX1 recombinant protein (Position: M1-E145). Human PDX1 shares 87.7% and 86.9% amino acid (aa) sequence identity with mouse and rat PDX1, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PDX1

Antigène: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Autre désignation: PDX1

Sujet:

Background: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Gene Full Name: pancreatic and duodenal homeobox 1

ID gène: 3651

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location