PARK7/DJ1 anticorps (AA 2-189) (Cy3)

N° du produit ABIN8019670

Cet anticorps anti-PARK7/DJ1 Monoclonal Souris conjugué à Cy3 (Clone 4B10) (ABIN8019670) détecte spécifiquement PARK7/DJ1 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PARK7/DJ1 anticorps (AA 2-189) (Cy3) (ABIN8019670)

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PARK7/DJ1 est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Clone: 4B10

Détail du produit anti-PARK7/DJ1 anticorps (Cy3)

Épitope: AA 2-189

Fonction: Anti-PARK7/DJ1 Antibody (monoclonal, 4B10) Cy3 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse,rat PARK7.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PARK7 recombinant protein (Position: A2-D189). Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse and rat PARK7.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PARK7/DJ1

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Autre désignation: PARK7

Sujet:

Background: Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.

Gene Full Name: Parkinsonism associated deglycase

ID gène: 11315

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport