PGC anticorps (AA 145-356)

N° du produit ABIN8020083

L’anticorps anti-PGC Polyclonal Lapin est utilisé pour la détection de PGC dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IHC, ELISA, IF et FACS.

Aperçu rapide pour PGC anticorps (AA 145-356) (ABIN8020083)

Antigène: PGC (Pepsinogen C (PGC))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PGC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Détail du produit anti-PGC anticorps

Épitope: AA 145-356

Fonction: Anti-PGC Antibody

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PGC shares 69.5%,70% amino acid (aa) sequence identity with mouse,rat PGC,respectively.

Attributs du produit: Anti-PGC Antibody. Tested in ELISA, IF, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PGC recombinant protein (Position: Y145-N356). Human PGC shares 69.5% and 70% amino acid (aa) sequence identity with mouse and rat PGC, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat Immunofluorescence, 5 μg/mL, Human, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PGC

Antigène: PGC (Pepsinogen C (PGC))

Autre désignation: PGC

Sujet:

Background: Progastricsin also known as pepsinogen C or pepsinogen II is a pepsinogen precursor of the enzyme gastricsin that in humans is encoded by the PGC gene. This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene Full Name: progastricsin

Poids moléculaire: 38 kDa

ID gène: 5225

UniProt: P20142